There are several versions of hyaluronan injections — also called viscosupplementation — that are used to treat osteoarthritis of the knee. They are injected directly into the joint. They include:Euflexxa, Hyalgan, Orthovisc, Supartz, Synvisc

Side Effects

Potential side effects include joint swelling and pain. They can’t be used by people with skin or joint infections. In addition, most varieties are made from processed chicken or rooster combs and should not be used in people with egg or poultry allergies. Euflexxa, however, is safe to use in people with egg allergies.

Occasionally, a severe reaction with swelling, redness, and pain, called a pseudoseptic reaction, can occur with some forms of these viscosupplementation materials, especially if the course of 3 to 5 injections is repeated.